Authorities would have us believe cannabis, marijuana, weed, pot or whatever you call it is dependence forming. Is there any research behind this claim, or is it fear mongering? While no direct cause and effect link has been nailed down, there is an association. The binding site for THC is the CB1 receptor (CB1R). Differences in genetic makeup can result in the body having several different variant blueprints for building the CB1Rs. It’s several of these variants that are associated with cannabis dependence.